Ing. Karel Pauk, Ph.D.

EmployeeKarel Pauk

Date of Birth:               1985
Place of Birth:               Zábřeh, Czech Republic
Nationality:                  Czech
Work Phone:                +420 46 603 7742
Laboratory No.:            F03 042

Research topic

Potential new synthetic route for preparation of veterinary drug Alfaprostol (project of technologic agency of Czech Republic)


  • 2009 – 2014 University of Pardubice, Faculty of Chemical Technology (doctoral degree)
    Dissertation Thesis: Synthesis and biological activity of N-aryl/alkyl-salicylamidesand their precursors (defended ……… 2014)
  • 2007 – 2009 University of Pardubice, Faculty of Chemical Technology (masters’s degree)
    Diploma Thesis: Synthesis and conditioning Pigment Red 188 (defended …..2009)
  • 2004 – 2007 University of Pardubice, Faculty of Chemical Technology (bachelor’s degree)
    Bachelor Thesis: Anhydrides of aromatic di-and tetra-carboxylic acids in the synthesis of organic polycyclic pigments (defended ……. 2007)
  • 2000 – 2004 High School of Chemistry Pardubice. Specialization: Pharmaceutical substances


  • Imramovský, A.; Férriz, J.; Pauk, K. Synthetic Route for the Preparation of 2 Hydroxy-N-[1-(2-hydroxyphenylamino)-1-oxoalkan-2-yl]benzamides. J. Comb. Chem. 2010, 12, 414–416.
  • Imramovský, A.; Pauk, K.; Pejchal , V.; Hanusek, J. Salicylanilides and Their Derivates as Perspective Antituberculotics: Synthetic Routes and Biological Evaluation. Mini-Reviews in Organic Chemistry. 2011,8, 211-220.
  • Imramovský, A., Štěpánková, Š., Vanco, J., Pauk, K., Monreal-Férriz, J., Vinšová, J., Jampílek, J., Acetylcholinesterase-Inhibiting Activity of Salicylanilide, N-Alkylcarbamates and Their Molecular Docking. Molecules. 2012, 17, 10142-10158.
  • Imramovský, A., Pauk, K., Padělková, Z., Hanusek, J., Crystal Structure of the 5-Chloro Salicylamides: Three Different Types of the H-bonding Influenced Linear Chain Formation in the Solid State. Crystals. 2012, 2, 349-361.
  • Imramovský, A.; Jorda, R.; Pauk, K.; Rezníčková, E.; Dušek, J.; Hanusek, J.; Kryštof, V. Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines. Eur. J. Med. Chem. 2013, 68, 253-259.
  • Pauk, K.; Zadražilová, I.; Imramovský, I.; Hanusek, J.; Pokorná, M. Masaříková, M.; Čížek, A.; Jampílek, J. New derivatives of salicylamides: Their preparation and antimicrobial activity against various bacterial species. Bioorganic & Medicinal Chemistry. 2013, 21, 6574-6581.


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